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Step into the Mushroom Kingdom with this officially licensed Luigi costume. Premium quality materials and authentic details make this perfect for Halloween, cosplay, or gaming events.
Gaming costumes are trending this Halloween season. Check out our gaming and entertainment news for more costume inspiration.
Congratulations to The Times Athlete of the Week, Serena boys soccer and golf's Payton Twait!
The Michigan Wolverines didn't play this week, but they had some movement in the polls.
LOS ANGELES — For years, Matthew McConaughey wouldn't tell his mom, Kay, anything of substance during their weekly phone calls — her love of spreading news had cost her his trust.
Defense Secretary Pete Hegseth told the U.S. military’s senior-most officers Tuesday that he no longer wants to see “fat generals and admirals” or overweight troops. Addressing a crowded auditorium in Quantico, Va., Hegseth emphasized the need to stick to strict fitness standards, declaring every service member at every rank is required to take a physical [...]
Socialite and proud mom Paris Hilton, 44, has said her two children, Phoenix Barron and London Marilyn, have a very close bond
Naya Rivera’s son Josey is growing up so fast.And the proof is in his father Ryan Dorsey’s latest post in honor of his 10th birthday. “120 months...521.78 weeks 3,652 days gone by in a flash....,”...
Read the latest from Fox News Opinion & watch videos from Sean Hannity, Raymond Arroyo & more.
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Aimee Lou Wood is standing by her decision to call out “Saturday Night Live” over its portrayal of her in a “White Lotus” sketch earlier this year. In April, “SNL” player Sarah Sherman depicted Wood’s “White Lotus” character Chelsea with an exaggerated accent and large false teeth as the punch line to a joke about [...]
This Season of ‘Monster’ Digs Up an All-American Nightmare The New York TimesHow Charlie Hunnam Became the Serial Killer From Hell: Inside the Voice Recordings, Psychotic Breakdowns and Terrifying Murders in Ryan Murphy’s New ‘Monster’ VarietyWhy Netflix is portraying horrific serial killer Ed Gein as 'sexy' in season three of Monster LADbibleHow 'godfather of all serial killers' made masks from women's faces & lampshades from human skin in sick tribute to MUM MVNUMonster: The Ed Gein Story release date and Netflix timings confirmed The Scotsman
PBS will resume its children's TV show "Reading Rainbow" with a new host after 20 years. Here's what to know.
FOX News star Kat Timpf has opened up about stepping back into the studio after welcoming her first baby and battling breast cancer.The 36-year-old au
While Sweeney was the belle of her own ball in Britney Spears’ 2008 dress from The Blonds, guest Lauren Sánchez's look commanded attention.
TALLAHASSEE, Fla. (AP) — Florida officials decided Tuesday to set aside nearly three acres of prime downtown Miami real estate next to the historic Freedom Tower as a potential site of the future presidential library of President Donald Trump.
Speaking to The Atlantic, Dr. Mehrdad Hajibabaei, professor in the Department of Integrative Biology, discussed ongoing work to catalogue all life on Earth. [...]Read More... from Biologist Talks DNA Barcoding with The Atlantic
HILARIA Baldwin rips DWTS judges as ‘not credible’ in blink-and-you’ll-miss-it comment after near elimination.Alec Baldwin's wife Hilaria Baldwi
During his nearly hour-long speech, Hegseth said the U.S. military has promoted too many leaders for the wrong reasons based on race, gender quotas and “historic firsts.”
The Data Center Power Market is driven by the exponential surge in cloud adoption, the rising demand for energy-efficient power solutions, and the growth of hyperscale facilities worldwide. However, high capital costs, complex integration challenges, and increasing concerns over carbon...
The United States will deport hundreds of Iranians back to Iran in the coming weeks, Iran said Tuesday.
The NCAA is close to approving a single transfer window in college football
To dramatically increase coral survival rates, scientists at the University of Hawaiʻi at Mānoa Hawaiʻi Institute of Marine Biology (HIMB) have developed innovative 3D-printed ceramic structures that provide crucial protection for baby corals. These new designs offer a low-cost and scalable solution to enhance reef recovery worldwide.
ORLANDO, Fla. (AP) — Multiple people have reached out with related stories to the family of a 32-year-old man who died of blunt force injuries two weeks ago while riding the new Stardust Racers roller...
Psychology professor Samuel McDougle works to understand how cognition interacts with the body’s movements — as in musicians, for instance.
A social media video, verified by Reuters, shows brown and murky floodwaters in the streets of Ibiza, Spain, after a powerful storm hit the island.
A man who fell off a boat off the Massachusetts coast Tuesday was in critical condition, officials said.The boater fell into the water about five miles away from shore, and reported by someone who called 911 about 3:45 p.m. according to the Newburyport city marshal and fire department. People on the boat performed CPR as they headed to a dock on Plum Island Point, officials said, and first responders continued to give him CPR on the way to a local hospital. Officials didn’t share what’s believed to have led to his fall into the ocean. More Newburyport newsMassachusettsAug 4Police officer on motorcycle hurt in crash during traffic stop in NewburyportNewburyportJul 30‘Natural conversation': Newburyport uses tech to break down language barriers
Scientists warn that “flying rivers” — invisible streams of moisture that carry rain from the Atlantic Ocean westward across the Amazon — are weakening as deforestation and climate change advance. That's because the trees that are being lost are crucial...
Incoming FAS faculty member Xiang Zhou is developing novel computational and statistical methods to help other scientists understand the genetic drivers of disease.
The Habitable Worlds Observatory is poised to tell us whether Earthlike planets are common—if it can get off the ground
Many people look at trees to relax, taking in the soothing fractal patterns to adjust their eyes from too many hours spent at a computer. Dominick "Dom" Ciruzzi, assistant professor of geology at William & Mary, takes tree watching to a whole new level. An ecohydrologist, Ciruzzi is fascinated by how ecosystems and water interact, and he's taken a special interest in arboreal life.
Dr. George diCenzo, Associate Professor at Queen's University (Canada) has been awarded the 2025 J. Roger Porter Award in recognition of his visionary leadership in developing the Canadian Collection of Agricultural Soil Microbes.
Microlightning might provide long-sought explanation for will-o'-the-wisps Phys.orgWe may finally know what causes will-o’-the-wisps New ScientistThe Mystery of Ghostly Will-o’-the-Wisps May Finally Be Solved Scientific AmericanMysterious will-o’-the-wisps ignited by microlightning Science | AAASGhostly Swamp Lightning Explained Nautilus | Science Connected
Surveying Io's Surface with the UNAGI lander Phys.org
Billions of years ago, water flowed across Mars. Most scientists agree the red planet had rivers. But did those rivers flow into an ocean? New research from the University of Arkansas found strong evidence in Mars' geology of an ocean in the planet's northern hemisphere.
Simulating Habitable Worlds Observatory's ability to characterize Earth-sized exoplanets Phys.org
The Berkshire Innovation Center will host TEDx Berkshires from 2 to 5 p.m. Thursday, Oct. 9, at 45 Woodlawn Ave., featuring talks from a diverse group of thought leaders.
Now that we know what Denisovans looked like, they’re turning up everywhere.
"No one is coming to save us."The post Whistleblowers Say NASA Is Poised to Kill an Astronaut appeared first on Futurism.
The Food Safety and Inspection Service said that the products were recalled over suspicions that there were pieces of wood in the corn dog batter
SCHUYLERVILLE — There are approximately 500 adult-use cannabis dispensaries across New York State. Brownies, one of the first to be sited in the state is now also among its latest, with a grand opening celebration of the brand’s second location...
WASHINGTON (Reuters) -A federal judge in Washington ordered the Trump administration on Monday to pause the layoffs of hundreds of employees from the agency that owns the U.S. news service Voice of America, adding that government officials had shown "concerning disrespect" for the court's directives. U.S. District Judge Royce Lamberth halted the plan while he determines whether the U.S. Agency for Global Media complied with an injunction he issued in April that it "fulfills its statutory mandate that VOA serve as a consistently reliable and authoritative source of news." VOA broadcasts were abruptly shut down in March under an executive order from U.S. President Donald Trump.
Heller scores in OT to lift Audubon past Gateway -- Boys soccer recap
HULU has suddenly canceled a comedy series after just one season, and the show's creator reacted to the news.The streamer pulled the plug on the sitco
No. 10 Morris Knolls over Kearny - Girls soccer recap
Penalties and fumbles ruined any chances the Jets had of capturing the first win of the Aaron Glenn era
Here are the answers for The New York Times Mini Crossword for Sept. 30.
Rutgers Wrestling Finalizes its 2025-2026 schedule.
Noah Laba is making it tough for the New York Rangers to keep him off the opening-night roster. The 22-year-old
The feud between rival north St. Louis County Democrats appears to have escalated Thursday night, with a county councilwoman alleging she was assaulted by two of her rivals.
The Somonauk/Leland/Newark boys soccer team defeated host Serena on Monday 6-0 to clinch the Little Ten Conference regular-season championship and finish the league schedule unscored on.
Falcons sweep three close doubles matches to beat Dragons
SHANGHAI, Sept. 29, 2025 /PRNewswire/ -- From September 24 to 26, InnoMax Medical Technology Co., Ltd. (InnoMax MedTech) featured its portfolio of proprietary products at 2025 Medtec China, spanning medical imaging and respiratory care. Among them was the company's proprietary Portable...
CLEVELAND — Detroit's Tarik Skubal will be back on the mound at Progressive Field on Tuesday for the first game of the AL Wild Card Series against Cleveland.
The Jets committed 13 penalties and fumbled the ball three times on Monday night in Miami, losing 27-21 to the Dolphins and falling to 0-4 on the season.
Rhea Ripley is headed to Crown Jewel: Perth with 20/20 vision. Her match is official — and personal.
After nearly two seasons away from NFL action, Darren Waller returned as a frequent red-zone target for Miami.
After three seasons, including a 2023 World Series win, Bruce Bochy is out as manager of the Texas Rangers.
WILLIAMSBURG — Nick Shearer’s Whitley County Lady Colonels got a big win on Monday, defeating Somerset, 2-1.
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Trump: 'Release The E---arhart Files!' President Donald Trump has finally done it... the thing we've all been waiting for: WE'RE GETTING EARHART FILESAmelia Earhart poses for photos as she arrives in Southampton, England, after her transatlantic flight on the "Friendship" from Burry Point, Wales, on June 26, 1928. AP Photo/FileIndeed, on Friday Trump ordered the release of records related to legendary pilot Amelia Earhart and her ill-fated attempt to become the first female pilot to circumnavigate the world at the age of 39. "I have been asked by many people about the life and times of Amelia Earhart, such an interesting story, and would I consider declassifying and releasing everything about her, in particular, her last, fatal flight," Trump wrote on Truth social, instead of releasing the list of powerful Epstein associates who systematically raped young women, over and over. "I am ordering my Administration to declassify and release all Government Records related to Amelia Earhart, her final trip, and everything else about her," Trump continued (likely after watching some documentary the other night).As the Epoch Times notes further, Earhart made history in 1932 as the first woman to fly nonstop and solo across the Atlantic. By 1936, she was preparing to fly around the world with navigator Frederick Noonan, but their first attempt ended in Hawaii due to technical problems.In May 1937, the pair made a second attempt, flying East. After reaching New Guinea, they set off toward Howland Island, a tiny speck of land with an airstrip lying about halfway between Hawaii and Australia. They never arrived.Earhart and Noonan’s disappearance sparked one of the largest government rescue missions of its time, involving an aircraft carrier with 54 aircraft, a Coast Guard ship, two destroyers, and a battleship.Despite the massive operation, no trace of the aviators or their plane was ever found. On July 19, 1937, the U.S. Navy called off the search, and Earhart and Noonan were presumed dead.The incident remains one of aviation’s enduring mysteries. Over the decades, teams of public and private expeditions have searched the Pacific in hopes of finding wreckage of Earhart’s aircraft, but none have succeeded.Different theories about her fate have emerged, including the claim that she was captured by Japan—at a time of tense relations with the United States—and executed under suspicion of being a spy.“Amelia made it almost three-quarters around the World before she suddenly, and without notice, vanished, never to be seen again,” Trump wrote in his Truth Social post.“Her disappearance, almost 90 years ago, has captivated millions.”Trump has shown a recurring interest in declassifying files connected to historical mysteries. In January, shortly after returning to the White House, he directed officials to prepare the release of documents related to the assassinations of John F. Kennedy, Robert F. Kennedy, and Martin Luther King Jr. Tyler DurdenMon, 09/29/2025 - 22:45
NFL Week 4 Recap: Immediate fantasy football takeaways from Monday Night Football PFFWeek 4 'MNF' overreactions: Tyreek Hill's career over? Aaron Glenn on hot seat? CBS SportsNFL Week 4 grades: Giants earn an 'A' for huge upset over Chargers, Ravens fail out for blowout loss to Chiefs CBS SportsUnc DEMANDS Ocho CAN'T SAY FOOT or BALL as his Broncos WHOOP the Bengals 28-3!!| Nightcap BVM SportsColin Cowherd Podcast - INSTANT REACTION to Bengals-Broncos & Jets-Dolphins FOX Sports Radio
Google withdrew its rezoning proposal to build a data center in Marion County's Franklin Township. Former Indianapolis Mayor Greg Ballard emphasized the importance of considering the number of jobs created and incentives offered from data center projects.
Two weeks remain in the Western Pennsylvania Interscholastic Softball League regular season, and Bethel Park (10-0) and Montour (8-0) hope to remain undefeated.
Somonauk/Leland/Newark shut out Serena 6-0 on Monday, Sept. 29, 2025 at Serena High School. Check out photos from the game by MaKade Rios.
The little town of Carrboro, North Carolina has sued utility giant Duke Energy for damages from climate change. The post North Carolina Town Sues Duke Energy For Damages Caused By “Climate Deception” appeared first on CleanTechnica.
Colombian officials said Monday the country has produced its first combat rifle, a cheaper, lighter weapon aimed at replacing the arms that were once supplied its former military ally Israel.
China’s PMI data show stronger orders, yet job cuts and profit pressures deepen. Markets eye Beijing’s policy pledges as Golden Week begins.
YouTube has settled a lawsuit with Donald Trump for $24.5 million over his 2021 account suspension, with $22 million funding a new White House ballroom. This follows similar payouts from Meta and X, highlighting tensions between tech giants and conservatives alleging censorship. The deal raises concerns about litigation influencing political projects.
The official manufacturing purchasing managers' index was 49.8, versus 49.4 in August, the National Bureau of Statistics said
ADB trims Asia growth forecast on U.S. tariffs, warns of further slowdown.Citi has trimmed its Brent crude price forecast for 2026 to $62 a barrel, from $65China private survey manufacturing PMI (September) 51.2 (expected 50.3, prior 50.5)China official manufacturing PMI (September) 49.8 (expected 49.6, prior 49.4)Australian building permits (August) -6.0% m/m (expected -5.5%)Australia Private Sector Credit (August) +0.6% (expected 0.6%, prior 0.7%)Boeing has started working on a 737 MAX replacement, new narrow-body plane in developmentPBOC sets USD/ CNY mid-point today at 7.1055 (vs. estimate at 7.1166)Trump signs proclamation imposing lumber tariffs, capped at 15% for EU, Japan.China Securities Journal: PBOC set to guide rates lower in Q4 to maintain liquidity.New Zealand business confidence steady in September at 49.6 vs. 49.7 priorBoJ split deepens: Hawks eye hikes, doves warn on risksBoJ Summary (September meeting) is barely shifting the yenJapan data - August retail sales -1.1% y/y (expected +1.0%)Japan data - August industrial production (preliminary) -1.2% m/m (expected -0.8%)Golden Week 2025: China shuts October 1–8, Hong Kong markets closed Octoner 1 and 7Shutdown? M'eh. UBS says the Federal Reserve will cut in October anyway.South Korea’s industrial output stalls, retail sales drop in AugustUK inflation - shop prices rise at fastest pace since February, BRC warns on leviesSaturday is the (time) line in the sand for the yen - Koizumi PM win could lift JPYRBA hold, preview. TD Securities: RBA unlikely to signal cuts as labour market stays firm.Goldman Sachs: Jobs data could decide equity-bond market splitUS Senate Minority Leader Schumer says he would NOT support a 7 to 10 day CR.Trump's shut down is the plan to allow mass, permanent, firings of Federal workersIf the US government shuts down there will be no NFP report on FridayUS' Schumer says its up to Republicans if they want to shut down - Trump pulls the stringsRBA today - preview: Westpac tips cash rate hold, still sees November cut as base case.investingLive Americas markets wrap: Gold keeps making recordsTrump announced fresh tariffs, this time targeting lumber and timber. Duties of 10% — capped at 15% for imports from Japan and the EU — will take effect on October 14, alongside 25% tariffs on kitchen cabinets and some wooden furniture. The dollar briefly popped on the news but failed to hold gains.From Japan, the Bank of Japan’s September Summary of Opinions provided more colour on the policy debate. While it was already known that two board members pushed for a rate hike at the meeting, the document shed further light on the divide between hawks advocating for a return to normalisation and doves urging caution. The yen saw only minor moves and is little changed overall.In China, official data showed factory activity contracted at a slower pace in September, with the NBS manufacturing PMI rising to 49.8 versus 49.5 expected — its strongest since March, though still below the 50 threshold. A private survey by RatingDog was more upbeat, with its PMI climbing to 51.2, beating forecasts and marking the highest reading since May.Markets now turn to the Reserve Bank of Australia decision at 0430 GMT, followed by Governor Michele Bullock’s press conference. The RBA is widely expected to hold the cash rate steady, though traders will focus on guidance amid sticky inflation and a resilient labour market clouding the outlook for further cuts.Asia-Pacstocks:Japan(Nikkei 225) -0.05%HongKong (Hang Seng) +0.09%ShanghaiComposite +0.25%Australia(S&P/ASX 200) -0.01% This article was written by Eamonn Sheridan at investinglive.com.
Equities rallied for a second day and gold hit another record Tuesday on growing Federal Reserve interest rate optimism, though traders were preparing for a possible US government shutdown that could affect the release of key economic data. A string of closely watched indicators has recently supported investor expectations that the US central bank will [...]The post Stocks rise, gold hits record as rate cuts and shutdown loom appeared first on Digital Journal.
SIDOARJO, Indonesia (AP) — Rescuers ran oxygen and water to students trapped in the unstable concrete rubble of a collapsed school building in Indonesia, as they desperately worked to free survivors Tuesday morning more than 12 hours after the structure...
Trump and Netanyahu say they've agreed on a plan to end the Gaza war. Hamas is now reviewing it
JK Rowling has responded after Emma Watson made conciliatory comments in a podcast posted Wednesday about their relationship which has been marked for years by conflicting views on transgender rights.On Monday, JK Rowling posted to her 14.4 million X followers a nearly 700-word response to Emma Watson’s latest remarks about their ongoing conflict. “Emma Watson and her co-stars have every right to embrace gender identity ideology,” Rowling wrote. “Such beliefs are legally protected, and I wouldn’t want to see any of them threatened with loss of work, or violence, or death, because of them.”She then targeted Watson and her “Harry Potter” co-star Daniel Radcliff for their public critiques of the author’s views.“However, Emma and Dan in particular have both made it clear over the last few years that they think our former professional association gives them a particular right — nay, obligation — to critique me and my views in public.”Rowling said that until recently she felt a “certain protectiveness” over Watson and her co-stars who she has known since they were ten-years-old, stating that she has “repeatedly declined invitations from journalists to comment on Emma specifically.”Books and literatureJun 26San Francisco bookstore stops selling J.K. Rowling titles due to ‘Harry Potter' author's anti-trans viewsTransgender rightsApr 2, 2024J.K. Rowling will not be arrested for comments about transgender women, police sayJun 9, 2020Radcliffe Reacts to Rowling Controversy: ‘Transgender Women Are Women'The author said the actor “has so little experience of real life she’s ignorant of how ignorant she is.”Rowling later compared her own background of poverty to Watson’s “privileges.”“I wasn’t a multimillionaire at 14. I lived in poverty while writing the book that made Emma famous,” Rowling wrote. “I therefore understand from my own life experience what the trashing of women’s rights in which Emma has so enthusiastically participated means to women and girls without her privileges.”Rowling’s remarks on X came after Watson discussed her feelings toward Rowling in a sit-down interview for the “On Purpose with Jay Shetty” podcast posted Wednesday. When asked by Shetty how she’s dealing with Rowling’s “extremely hurtful” comments following their public break over transgender issues, Watson said that she still treasures their relationship.“I really don’t believe that by having had that experience, and holding the love and support and views that I have, mean that I can’t and don’t treasure Jo and the person that I had personal experiences with.”She continued, saying that she hopes “people who don’t agree with my opinion will love me, and I hope I can keep loving people who I don’t necessarily share the same opinion with.”Watson’s manager did not immediately reply to an NBC News request for comment.
Doja Cat is painting most of the world red with her latest announcement.
Costa Rica's Fire Department said it rescued 48-year-old Mauricio Hoyos from the attack and carried him on a 36-hour journey from Cocos Island.
Michelle Pfeiffer was a smooth rider into the newest phase of her life.The Grease 2 actress, 67, revealed that she recently became a first-time grandmother, which has impacted how much of her...
Technical issues are an unfortunate part of any live event, and even for those as experienced and on top of things as the WWE team, things still unfortunately go wrong from time to time. While most of the show went off without a hitch, that wasn’t the case during the entrance of the American Nightmare [...]The post Fans Confused After WWE Botches Cody Rhodes’ Entrance on Raw appeared first on ComicBook.com.
Darren Waller had a pair of touchdown catches in his first NFL game in nearly two years, and Tua Tagovailoa threw for 177 yards to lead the Miami Dolphins to their first win of the season, 27-21 over the New...
Keith Urban praised Nicole Kidman for sticking by him during a tumultuous time in their marriage just one year before the pair called it quits. Urban, 57, gave a heartfelt speech honoring his wife at the 49th AFI Life Achievement Award Gala in April 2024, recalling how he caused problems in the relationship amid his [...]
Video gamer Electronic Arts to be bought in largest-ever private equity buyout valued at $55 billion
At least 65 students are presumed buried under the rubble of an Islamic school building that collapsed in Indonesia.
LOS ANGELES (AP) — A woman who was knocked unconscious and arrested by two sheriff’s deputies in Northern California after stopping to change drivers during a family trip in 2020 has reached a $...
After a chorus of comics slammed the lineup of stand-ups participating in Saudi Arabia’s Riyadh Comedy Festival, Arrested Development alum David Cross is also voicing his staunch disapproval. In a statement shared to Instagram, the comedian and actor wrote that he’d been asked for his opinion on the matter a number of times and, as [...]
Bronny spoke about his father, LeBron at Lakers media day
The live streaming of the India vs Sri Lanka ICC Women's World Cup 2025 match will be available on the Sony LIV app and website in India.
Real, human actors are not happy with the possibility of AI actress Tilly Norwood possibly getting a Hollywood agent. The backlash started over the weekend when the news went live that talent agents were quietly looking to sign Tilly. There was an immediate uproar online, with actors and social media users making their opinion on [...]
Austin's biggest music event is back, and the city is gearing up to welcome 75,000 people a day. Whether you're going or not, there are things you'll want to know ahead of the packed two weekends ahead.
Bad Bunny tapped for Super Bowl halftime, spotlighting Latin pride and his clashes with Trump
Harvard researcher Avi Loeb says comet 3I/ATLAS weighs 33 billion tons and spans 3.1 miles, making it far larger than previous interstellar visitors.
As the federal government nears a potential shutdown, a report by Senate Democrats alleges that NASA is already taking steps in to carry out the administration’s proposed budget.The post Report claims NASA taking illegal steps to implement budget proposal appeared first on SpaceNews.
CRISPR drives breakthroughs in editing, diagnostics, and agriculture. A new study traces the versatile Type V Cas12 branch to a pivotal RNA-splitting event that transformed ancient transposons into today’s genome-editing immune systems.The post CRISPR’s Origin Story: RNA Splitting Sparked Rise of Type V Systems appeared first on GEN - Genetic Engineering and Biotechnology News.
The first manned mission to fly around the moon in more than 50 years could launch as early as February 2026.
A Mexican marine biologist has been seriously injured by a shark off Costa Rica’s Pacific coast
What type of lander could touch down on Jupiter’s volcanic moon, Io? This is what a recent paper presented at the AIAA 2025 Regional Student Conference hopes to address as a team of student engineers from Spartan Space Systems at San Jose State University investigated a novel concept for landing a spacecraft in Io, which is the most volcanically active planetary body in the solar system. This study has the potential to help scientists and engineers develop new mission concepts from all levels of academia and industry.
CORVALLIS, Ore. – New research into antimicrobial peptides, small chains of amino acids able to damage bacterial cells, shows why some peptides are more effective at doing that and also why some cells are more vulnerable.The findings open the door to designing novel compounds for killing disease-causing organisms that have become resistant to antibiotics. These compounds would represent a major breakthrough against a pervasive global problem, said study co-leader Myriam Cotten of Oregon State University.“Antimicrobial resistance is a growing threat throughout the world,” said Cotten, associate professor of biochemistry and biophysics in the OSU College of Science. “In 2021, almost 5 million people died of antimicrobial resistance. Almost 40 million are predicted to die of it between 2025 and 2050.”Found in all living things, peptides have a variety of forms and functions, including as hormones, neurotransmitters, and signaling molecules in cells. As antimicrobials, they help make up the first line of defense against bacterial infection, often by causing bacterial cells’ contents to leak out of the membrane, compromising cellular function.The research by Cotten and collaborators at William & Mary and the National Institutes of Health focused on the specific states that give rise to membrane disruption. The study combined lab experiments with computational work conducted by the NIH’s National Heart, Lung, Blood Institute and shed light on the characteristics of the holes, known as pores, that antimicrobial peptides form in membranes. The pores form when the peptides that coat the outside of the cell start flipping across the membrane to balance out their numbers on each side.“This information is very powerful since it provides the basis to explain why some peptides are more active than others and why some membranes are easier to target,” Cotten said. “We learned that the peptides that disrupt membranes more dramatically form pores in the membranes that are larger in size and number and stay open longer. It makes sense but the crucial novelty of our work is that we now have a mathematical equation that relates the effectiveness of membrane damage and pore characteristics. We can start applying it to identify properties required for optimal efficacy.”The scientists also found that certain membranes carry defects that help peptides form that type of pore, insight that opens the door to designing peptides that specifically target bacterial cells based on their distinct membrane composition.The findings are applicable to therapies beyond those for treating infectious diseases, Cotten added, since immune-system peptides are active on cancer cells as well. New cancer treatments are urgently needed, she noted, as more than 2 million new cancer diagnoses and more than 500,000 cancer deaths are predicted for the United States in 2025.The research, supported by the National Institutes of Health and co-led by the NIH’s Richard Pastor, was published in the Proceedings of the National Academy of Sciences.
The anomaly came about a month after the FAA issued a Return to Flight determination for Firefly’s Alpha rockets following an anomaly experienced during Alpha Flight 6 in April.
A honeybee hive, with its large stores of pollen, wax, and honey, is like a fortress guarding treasure: with strong defenses, but a bonanza for enemies that can overcome those. More than 30 parasites of honeybees are known, spanning protists, viruses, bacteria, fungi, and arthropods—and this number keeps growing. As a result, beekeepers are always on the lookout for new ways to protect their precious hives.
30 September 2025 - Swedish clinical-stage pharmaceutical company Vicore Pharma Holding AB (STO:VICO) announced on Tuesday that Japan's Ministry of Health, Labor and Welfare has granted Orphan Dr...
With new emulator, cosmologists can explore data faster than thought possible
30 September 2025 - Swiss pharmaceutical company Novartis Pharma AG (SIX:NOVN) (NYSE:NVS) announced on Monday that it plans to launch a direct-to-patient (DTP) platform in the United States which will...
Discover Louis Navellier's method for finding top growth stocks like Carvana, focusing on strong earnings momentum, soaring sales, and expanding profitability.